FORMULATION AND EVALUATION OF PHYTOSOME LOTION FROM NOTHOPANAX SCUTELLARIUM LEAF EXTRACT FOR HAIR GROWTH

نویسندگان

چکیده

Objective: The purpose of this study was to formulate a phytosome lotion from Mangkokan leaf using green solvent extraction. Methods: Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, combined with microwave-assisted extraction, used obtain flavonoid compounds. extract formulated into three different ratios phospholipon (1:0.5), (1:1), and (1:2). Three formulas were analyzed identify the best formula. analysis included morphology, particle size, zeta potential, entrapment efficiency, spectrum an FTIR spectrophotometer. formula which chosen concentration (20%; 25%; 30%) then, evaluated for physical stability, hair growth activity test length, weight, diameter. Minoxidil non-phytosome as comparison. Data two-way ANOVA. Results: confirmed complex formation phospholipon. morphology displayed irregular spherical vesicles. Phytosome ratio (1:0.5) because has smaller size (289 nm), higher efficiency (99.76%±0.24) than others. lotions 2% minoxidil (p = 0.0001). (30%) thus showed highest efficacy weight Conclusion: that extracted tetrafluoroborate extraction then minoxidil. Lotion contains 30% mangkokan efficacy.

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ژورنال

عنوان ژورنال: International Journal of Applied Pharmaceutics

سال: 2021

ISSN: ['0975-7058']

DOI: https://doi.org/10.22159/ijap.2021v13i6.42169